Abstract:

Recent success in using high-intensity focused ultrasound (HIFU) for surgical applications has stimulated the development of image-guided systems for noninvasive therapy. With the goal of developing an all-ultrasound modality, we have developed a clinical HIFU system comprising an integrated transducer probe that permits precisely registered HIFU therapy delivery and high-quality ultrasound imaging, a multi-channel signal generator and rf amplifier system, and a software program that provides the clinician with a graphical overlay of the ultrasound image and therapeutic protocol controls. Electronic phasing of the 2-MHz HIFU annular array allows adjusting the focus within the range of about 4--12 cm from the face. A central opening in the transducer permits mounting of a commercial medical imaging scanhead (ATL P7-4) that is held in place within a special housing. This mechanical fixture ensures precise registration between the HIFU transducer axis and the image plane of the imaging probe. We will present a description of the various system components along with experimental in vitro results of therapy targeting and lesion visualization.